Increased spread of electrotonic potentials during diastolic depolarization in cardiac muscle.
Enviado por Walmor Carlo De Mello el
Título | Increased spread of electrotonic potentials during diastolic depolarization in cardiac muscle. |
Publication Type | Journal Article |
Year of Publication | 1986 |
Autores | De Mello, W |
Journal | J Mol Cell Cardiol |
Volume | 18 |
Issue | 1 |
Pagination | 23-9 |
Date Published | 1986 Jan |
ISSN | 0022-2828 |
Palabras clave | Animals, Diastole, Dogs, Electric Conductivity, Epinephrine, Heart, In Vitro Techniques, Membrane Potentials, Myocardial Contraction, Purkinje Fibers |
Abstract | The spread of electrotonic potentials during diastolic depolarization was measured in canine Purkinje fibres immersed in normal Tyrode solution. The results indicate that the space constant is gradually enhanced during the pacemaker potential reaching an optimum before the firing of the action potential. The increase in space constant is mainly due to a rise in rm but a decline in ri was also found. Epinephrine (1 microgram/ml) increased the spread of electrotonic potentials during diastolic depolarization. Assuming that the myoplasmic resistivity is not changing during the pacemaker potential the results obtained might indicate an increase in junctional conductance during this phase of cardiac cycle. |
Alternate Journal | J. Mol. Cell. Cardiol. |
PubMed ID | 3950969 |
Grant List | HL 30614 / HL / NHLBI NIH HHS / United States |