Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression.
Enviado por Luis Montaner el
Título | Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression. |
Publication Type | Journal Article |
Year of Publication | 2003 |
Autores | Papasavvas, E, Sandberg, JK, Rutstein, R, Moore, EC, Mackiewicz, A, Thiel, B, Pistilli, M, June, RR, Jordan, KA, Gross, R, Maino, VC, Nixon, DF, Montaner, LJ |
Journal | J Infect Dis |
Volume | 188 |
Issue | 6 |
Pagination | 873-82 |
Date Published | 2003 Sep 15 |
ISSN | 0022-1899 |
Palabras clave | Adolescent, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Child, HIV Infections, HIV-1, Humans, Immunologic Memory, Immunophenotyping, Lymphocyte Activation, RNA, Viral, Viral Load |
Abstract | The present study assessed antiviral T cell immune responses in 48 human immunodeficiency virus (HIV)-infected children with a stable or decreasing CD4(+) T cell counts and different levels of viral control, in the presence or absence of antiretroviral therapy. Children with full (<40 copies/mL) or partial (<50,000 copies/mL) virus suppression and with a history of stable CD4(+) T cell counts had significantly increased levels of anti-HIV CD4(+) T cell lymphoproliferative responses, lower levels of CD38(+), and higher CD8(+)/CD28(+) T cell percentage, compared with those in treated children with a lack of virus suppression (>50,000 copies/mL). Levels of anti-HIV CD8(+) T cell activity, although higher in treated children with a lack of virus suppression, were not significantly different between the groups. Although levels of anti-HIV CD4(+) and CD8(+) T cell responses were not associated, these levels of responses were associated with the percentage of specific T cell subsets. Overall, a history of stable CD4(+) T cell counts, as a result of therapy that imparted full or partial virus suppression, was associated with increased levels of anti-HIV CD4(+) T helper responses and decreased T cell activation. |
DOI | 10.1086/377645 |
Alternate Journal | J. Infect. Dis. |
PubMed ID | 12964119 |
Grant List | AI44595 / AI / NIAID NIH HHS / United States AI48398 / AI / NIAID NIH HHS / United States MH 01584 / MH / NIMH NIH HHS / United States |