Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells.
Enviado por Gilberto J Soler-Llavina el
Título | Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Autores | Soler-Llavina, GJ, Sabatini, BL |
Journal | Nat Neurosci |
Volume | 9 |
Issue | 6 |
Pagination | 798-806 |
Date Published | 2006 Jun |
ISSN | 1097-6256 |
Abstract | Here we demonstrate that cerebellar stellate cells diffusionally isolate synaptically evoked signals in dendrites and are capable of input-specific synaptic plasticity. Sustained activity of parallel fibers induces a form of long-term depression that requires opening of calcium (Ca(2+))-permeable AMPA-type glutamate receptors (CP-AMPARs) and signaling through class 1 metabotropic glutamate receptors (mGluR1) and CB1 receptors. This depression is induced by postsynaptic increases in Ca(2+) concentration ([Ca(2+)]) and is limited to activated synapses. To understand how synapse-specific plasticity is induced by diffusible second messengers in aspiny dendrites, we examined diffusion of Ca(2+) and small molecules within stellate cell dendrites. Activation of a single parallel fiber opened CP-AMPARs, generating long-lived Ca(2+) transients that were confined to submicron dendritic stretches. The diffusion of Ca(2+) was severely retarded due to interactions with parvalbumin and a general restriction of small molecule mobility. Thus stellate cell dendrites spatially restrict signaling cascades that lead from CP-AMPAR activation to endocannabinoid production and trigger the selective regulation of active synapses. |
DOI | 10.1038/nn1698 |
Alternate Journal | Nat. Neurosci. |
PubMed ID | 16680164 |
Grant List | 1 F31 NS049655-01 / NS / NINDS NIH HHS / United States R01 NS046579 / NS / NINDS NIH HHS / United States |