Chronic inflammatory responses to microgel-based implant coatings.
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Título | Chronic inflammatory responses to microgel-based implant coatings. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Autores | Bridges, AW, Whitmire, RE, Singh, N, Templeman, KL, Babensee, JE, L Lyon, A, García, AJ |
Journal | J Biomed Mater Res A |
Volume | 94 |
Issue | 1 |
Pagination | 252-8 |
Date Published | 2010 Jul |
ISSN | 1552-4965 |
Abstract | Inflammatory responses to implanted biomedical devices elicit a foreign body fibrotic reaction that limits device integration and performance in various biomedical applications. We examined chronic inflammatory responses to microgel conformal coatings consisting of thin films of poly(N-isopropylacrylamide) hydrogel microparticles cross-linked with poly(ethylene glycol) diacrylate deposited on poly(ethylene terephthalate) (PET). Unmodified and microgel-coated PET disks were implanted subcutaneously in rats for 4 weeks and explants were analyzed by histology and immunohistochemistry. Microgel coatings reduced chronic inflammation and resulted in a more mature/organized fibrous capsule. Microgel-coated samples exhibited 22% thinner fibrous capsules that contained 40% fewer cells compared to unmodified PET disks. Furthermore, microgel-coated samples contained significantly higher levels of macrophages (80%) than unmodified PET controls. These results demonstrate that microgel coatings reduce chronic inflammation to implanted biomaterials. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010. |
DOI | 10.1002/jbm.a.32669 |
Alternate Journal | J Biomed Mater Res A |
PubMed ID | 20166218 |
PubMed Central ID | PMC2875296 |
Grant List | R01 EB004496 / EB / NIBIB NIH HHS / United States R01 EB004496-04 / EB / NIBIB NIH HHS / United States R01-EB004496 / EB / NIBIB NIH HHS / United States |