Prefrontal control of fear: more than just extinction.
Enviado por Gregory Quirk el
Título | Prefrontal control of fear: more than just extinction. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Autores | Sotres-Bayon, F, Quirk, GJ |
Journal | Curr Opin Neurobiol |
Volume | 20 |
Issue | 2 |
Pagination | 231-5 |
Date Published | 2010 Apr |
ISSN | 1873-6882 |
Palabras clave | Affect, Amygdala, Animals, Association Learning, Behavior, Extinction, Psychological, Fear, Humans, Neural Pathways, Neuronal Plasticity, Prefrontal Cortex |
Abstract | Although fear research has largely focused on the amygdala, recent findings highlight cortical control of the amygdala in the service of fear regulation. In rodent models, it is becoming well established that the infralimbic (IL) prefrontal cortex plays a key role in extinction learning, and recent findings are uncovering molecular mechanisms involved in extinction-related plasticity. Furthermore, mounting evidence implicates the prelimbic (PL) prefrontal cortex in the production of fear responses. Both IL and PL integrate inputs from the amygdala, as well as other structures to gate the expression of fear via projections to inhibitory or excitatory circuits within the amygdala. We suggest that dual control of the amygdala by separate prefrontal modules increases the flexibility of an organism's response to danger cues. |
DOI | 10.1016/j.conb.2010.02.005 |
Alternate Journal | Curr. Opin. Neurobiol. |
PubMed ID | 20303254 |
PubMed Central ID | PMC2878722 |
Grant List | P50 MH086400 / MH / NIMH NIH HHS / United States P50 MH086400-015561 / MH / NIMH NIH HHS / United States R01 MH058883 / MH / NIMH NIH HHS / United States R01 MH058883-13 / MH / NIMH NIH HHS / United States R01 MH081975 / MH / NIMH NIH HHS / United States R01 MH081975-02 / MH / NIMH NIH HHS / United States |