Enalapril, an inhibitor of angiotensin converting enzyme, increases the junctional conductance in isolated heart cell pairs.
Enviado por Walmor Carlo De Mello el
PDF version| Título | Enalapril, an inhibitor of angiotensin converting enzyme, increases the junctional conductance in isolated heart cell pairs. |
| Publication Type | Journal Article |
| Year of Publication | 1991 |
| Autores | De Mello, W, Altieri, P |
| Journal | J Cardiovasc Pharmacol |
| Volume | 18 |
| Issue | 4 |
| Pagination | 643-6 |
| Date Published | 1991 Oct |
| ISSN | 0160-2446 |
| Palabras clave | Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Animals, Cyclic AMP, Enalapril, Heart Conduction System, Heart Ventricles, In Vitro Techniques, Membrane Potentials, Myocardium, Neuromuscular Junction, Propranolol, Protein Kinase Inhibitors, Rats, Renin-Angiotensin System, Vascular Resistance |
| Abstract | The effect of enalapril and angiotensin II on junctional conductance (gj) of isolated rat heart cell pairs was investigated. It was found that enalapril (1 micrograms/ml) increases gj by 106 +/- 3.1% (SEM) (n = 20) within 4 min. The effect of enalapril on gj was not suppressed by propranolol (10(-6) M) or by a cAMP-dependent protein kinase inhibitor. Angiotensin II (1 micrograms/ml) reduced gj by 55%. These observations might indicate that an intrinsic renin-angiotensin system in heart is involved in the control of gj in cardiac muscle. |
| Alternate Journal | J. Cardiovasc. Pharmacol. |
| PubMed ID | 1724543 |
