Increased β-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics.
Enviado por Frank Diaz el
Título | Increased β-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Autores | Paek, H, Antoine, MW, Diaz, F, Hébert, JM |
Journal | Dev Dyn |
Volume | 241 |
Issue | 2 |
Pagination | 242-6 |
Date Published | 2012 Feb |
ISSN | 1097-0177 |
Palabras clave | Animals, beta Catenin, Fibroblast Growth Factors, Mesencephalon, Mice, Mice, Mutant Strains, Neural Plate, Rhombencephalon, Telencephalon, Wnt Proteins |
Abstract | BACKGROUND: The early telencephalon shares molecular features with the early mid-hindbrain region. In particular, these two developing brain areas each have a signaling center that secretes FGFs and an adjacent one that secretes WNTs. WNTs and FGFs each play essential roles in regulating cell fates in both the telencephalon and mid-hindbrain. Despite this similarity, telencephalic and mid-hindbrain precursors express distinct genes and ultimately generate different cell types, tissue morphologies, and neural functions. RESULTS: Here we show that genetically increasing the level of β-catenin, a mediator of canonical WNT signaling, in the anterior neural plate causes a loss of telencephalic characteristics and a gain of mid-hindbrain characteristics. CONCLUSION: These results, together with previous ones demonstrating that increased WNT signaling in the anterior neural plate increases FGF expression, suggest that the levels of WNT and FGF signaling regulate telencephalic versus mid-hindbrain fates. |
DOI | 10.1002/dvdy.22787 |
Alternate Journal | Dev. Dyn. |
PubMed ID | 22102609 |
PubMed Central ID | PMC3266450 |
Grant List | MH083804 / MH / NIMH NIH HHS / United States R01 MH083804-01A1 / MH / NIMH NIH HHS / United States R01 MH083804-02 / MH / NIMH NIH HHS / United States R01 MH083804-03 / MH / NIMH NIH HHS / United States R01 MH083804-04 / MH / NIMH NIH HHS / United States T32 GM007288 / GM / NIGMS NIH HHS / United States |