Synthesis and characterization of novel polyanhydrides with tailored erosion mechanisms.
Enviado por María del Pilar Torres-González el
Título | Synthesis and characterization of novel polyanhydrides with tailored erosion mechanisms. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Autores | Torres, MP, Vogel, BM, Narasimhan, B, Mallapragada, SK |
Journal | J Biomed Mater Res A |
Volume | 76 |
Issue | 1 |
Pagination | 102-10 |
Date Published | 2006 Jan |
ISSN | 1549-3296 |
Palabras clave | Biocompatible Materials, Biodegradation, Environmental, Drug Carriers, Magnetic Resonance Spectroscopy, Materials Testing, Microscopy, Electron, Scanning, Polyanhydrides, Solubility, Surface Properties, Thermodynamics |
Abstract | We have designed a new synthesis route to create polyanhydrides based on monomers that contain hydrophilic entities within highly hydrophobic backbones. The method results in polyanhydrides that can be easily processed into drug-containing tablets. The synthesis, characterization, and erosion studies of polyanhydride copolymers based on 1,6-bis(p-carboxyphenoxy)hexane (CPH), which is highly hydrophobic, and 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG), which has hydrophilic oligomeric ethylene glycol segments in the monomer unit, was performed using a combination of molecular spectroscopy, thermal analysis, gravimetry, and scanning electron microscopy. The studies demonstrate that by increasing the CPH content in the CPTEG:CPH copolymers, the erosion of the system can be tailored from bulk-eroding to surface-eroding mechanism. These systems have promise as protein carriers. |
DOI | 10.1002/jbm.a.30510 |
Alternate Journal | J Biomed Mater Res A |
PubMed ID | 16138330 |